• Your autoinjector may have a speaker that provides voice instructions to help guide you through each step of the injection.
  • Even if the voice instructions do not work, the naloxone can still help reverse the overdose.

• When ready to use, pull EVZIO from the outer case.

• Pull off the red safety guard.

•Place the Black end of EVZIO against the outer thigh, through clothing, if needed. Press firmly and hold in place for 5 seconds.


•You may administer additional doses of naloxone every 2-3 minutes.